Ernő DUDA
Head, Principal Investigator

picture
Krisztina BUZÁS Staff Scientist
Kata JUHÁSZ Staff Scientist

REVERSE SIGNALING OF TUMOR NECROSIS FACTOR-ALPHA (TNF)

The main subject of the group has been the investigation of reverse signaling, one of the fine-tuning mechanisms of the immune response and the inflammatory reaction.


We studied reverse signaling in the tumor necrosis factor (TNF) – TNF receptor system. Modification of this bidirectional signaling promised the attenuation of the autoimmune reactions and host versus graft diseases.

The new project of the group project targets age-related macular degeneration (ARM), the leading cause of blindness in developed countries. This disease affects a high proportion of elderly people leading to significant deterioration of life quality and generation of societal problems.

A number of risk alleles of many genes are identified and environmental or behavioral factors, like diabetes, smoking, obesity and hypertension are also associated with the development of ARM. Still, the exact mechanisms are far from being known.

Our goal is to investigate the physiological and immunological background leading to druzen formation, neovascularization and loss of vision, to identify potential new targets for the treatment and especially the prevention of this debilitating disease.

Selected publications

Demeter, K., Herberth, B., Duda, E., Domonkos, A., Jaffredo, T., Herman, J.P. and Madarász, E. (2004). Fate of cloned embryonic neuroectodermal cells implanted into the adult, newborn and embryonic forebrain. Exp. Neurol. 188(2): 254-267.

Paszt, A., Takács, T., Rakonczay, Z., Kaszaki, J., Wolfard, A., Tiszlavicz, L., Lázár, G., Duda, E., Szentpáli, K., Czakó, L., Boros, M., Balogh, A. and Lázár G. Jr. (2004). The role of the glucocorticoid-dependent mechanism in the progression of sodium taurocholate-induced acute pancreatitis in the rat. Pancreas 29(1): 75-82.

Letoha, T., Somlai, C., Takács, T., Szabolcs, A., Jármay, K., Rakonczay, Z. Jr, Hegyi, P., Varga, I., Kaszaki, J., Krizbai, I., Boros, I., Duda, E., Kusz, E. and Penke, B. (2005). A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis. World J. Gastroenterol. 11(7): 990-999.

Letoha, T. Somlai, C., Takács, T., Szabolcs, A., Rakonczay, Z., Jármay, K., Szalontai, T., Varga, I., Kaszaki, J., Boros, I., Duda, E., Hackler, L., Kurucz, I. and Penke, B. (2005). The proteasome inhibitor MG132 protects against acute pancreatitis. Free Radic. Biol. Med. 39(9): 1142-1151.

Fejér, G., Szalay, K., Győry, I., Fejes, M., Kusz, E., Nedieanu, S., Páli, T., Schmidt, T., Siklódi, B., Lázár, Gy. jr., Lázár, Gy. sr. and Duda, E. (2005). Adenovirus infection dramatically augments lipopolysaccharide-induced TNF production and sensitizes to lethal shock. J. Immunol. 175(3): 1498-1506.

Letoha, T., Gaál, S., Somlai, C., Venkei, Z., Glavinas, H., Kusz, E., Duda, E., Czajlik, A., Peták, F. and Penke, B. (2005). Investigation of penetratin peptides. Part 2. In vitro uptake of penetratin and two of its derivatives. J. Pept. Sci. 11(12): 805-811.

Kis, K., Bodai, L., Polyanka, H., Éder, K., Pivarcsi, A., Duda, E., Soós, G., Bata-Csörgő, Z. and Kemény, L. (2006). Budesonide, but not tacrolimus, affects the immune functions of normal human keratinocytes. Int. Immunopharmacol. 6(3): 358-368.

Letoha, T., Kusz, E., Pápai, G., Szabolcs, A., Kaszaki, J., Varga, I., Takács, T., Penke, B. and Duda, E. (2006). In vitro and in vivo nuclear factor-kappaB inhibitory effects of the cell-penetrating penetratin peptide. Mol. Pharmacol. 69(6): 2027-2036.

Gyurján, I. Jr. Molnár, A., Borsy, A., Stéger, V., Hackler, L. Jr, Zomborszky, Z., Papp, P., Duda, E., Deák, F., Lakatos, P., Puskás L.G. and Orosz, L. (2007). Gene expression dynamics in deer antler: mesenchymal differentiation toward chondrogenesis. Mol. Genet. Genomics 277(3): 221-235.

Éder, K. Guan, H., Sung, H.Y., Ward, J., Angyal, A., Janas, M., Sarmay, G., Duda, E., Turner, M., Dower, S.K., Francis, S. E., Crossman, D. C. and Kiss-Tóth, E. (2008). Tribbles-2 is a novel regulator of inflammatory activation of monocytes. Int. Immunol. 20(12): 1543-1550.

Ábrahám, S. Szabó, A., Kaszaki, J., Varga, R., Éder, K., Duda, E., Lázár, G., Tiszlavicz, L., Boros, M. and Lázár, G. (2008). Kupffer cell blockade improves the endotoxin-induced microcirculatory inflammatory response in obstructive jaundice. Shock 30(1): 69-74.

Paszt, A., Éder, K., Szabolcs, A., Tiszlavicz, L., Lázár, G., Duda, E., Takács, T. and Lázár, G. (2008). Effects of glucocorticoid agonist and antagonist on the pathogenesis of L-arginine-induced acute pancreatitis in rat. Pancreas 36(4): 369-376.

Tubak, V., Határvölgyi, E., Krenács, L., Korpos, E., Kusz, E., Duda, E., Monostori, E. and Rauch, T. (2009). Expression of immunoregulatory tumor necrosis factor-like molecule TL1A in chicken chondrocyte differentiation. Can. J. Vet. Res. 73(1): 34-38.